Table 3.

SCCM/ESISM/ACCP/ATS/SIS diagnostic criteria for sepsis (2001).

SCCM/ESICM/ACCP/ATS/SIS Expanded diagnostic criteria for sepsis
Documented or suspected infection and some of the following:
General parameters: Fever Hypothermia Tachycardia Tachypnea Altered mental status Significant edema or positive fluid balance Hyperglycemia (in the absence of diabetes)
Inflammatory parameters: Leukocytosis Leukopenia Normal white blood cell count with > 10% immature forms Plasma C reactive protein >2 SD above normal value Plasma procalcitonin >2 SD above the normal value
Hemodynamic parameters: Arterial hypotension Mixed venous oxygen saturation >70% Cardiac index >3.5 1 min−1 m−2
Organ dysfunction parameters: Arterial hypoxemia Acute oliguria Creatinine increase Coagulation abnormalities Ileus Thrombocytopenia Hyperbilirubinemia
Tissue perfusion parameters: Hyperlactatemia Decreased capillary refill or mottling

Adapted from Levy et al. (34).