Table 4.

P I R O (sepsis patient staging system).

	P Predisposition	I Infection	R Response	O Organ dysfunction
Available	Age Comorbidities Chronic Conditions Baseline severity Source of admission	Pathogen Susceptibility Bacteremia Bacterial load Site of infection Nosocominal or community-acquired	Clinical resolution Hypoxemia Hypotension Immune response	ARDS Shock Acute renal failure MODS SOFA
Future	Genetics Polymorphisms of TLRs, IL-1, TNF and CD14	Genotyping Assay of microbial products Detection of virulence factors	Biomarkers	Mitochondrial dysfunction Endothelial damage and activation

Adapted from Levy et al. (34).