Table 3.
No. | Experiment 1 (5 days, 4-HMO) [piglets, n] | Experiment 2 (5 days, 25-HMO) [piglets, n] | Experiment 3 (11 days, 4HMO) [piglets, n] |
---|---|---|---|
NECa | |||
All piglets | −0.318nsc [17] | −0.722ns[18] | −0.316ns [16] |
NEC | −0.866ns [4] | −0.764**e [13] | −0.476ns [9] |
No NEC | −0.241ns [13] | −0.001ns [5] | −0.722ns [7] |
PERb | |||
All piglets | 0.121ns [8] | −0.318ns [11] | 0.400ns [4] |
NEC | n.d.d [2] | −0.866ns [3] | n.d. [2] |
No NEC | −0.116 ns [6] | −0.241ns [8] | n.d. [2] |
Cumulative NEC score: a score of ≥3 in any of the evaluated regions (stomach, proximal, middle, distal small intestine or colon) was defined as NEC.
Permeability: lactulose and mannitol contents were analyzed in urine and lactulose to mannitol concentration ratio was used as an indicator of intestinal permeability.
Significance was given at
P < 0.05 (ns = not significant).
n.d. = not determined. The limited sample size hampered detail statistical evaluation for subgroups.
Significant correlation for 2′FL (r = −0.67; P = 0.01), difucosyllactose (DF-L) (r = −0.69; P = 0.008), LNFP II (r = −0.72; P = 0.0039), LNT (r = −0.65; P = 0.0076), LNnT (r = −0.59; P = 0.0011) and disialyl-LNT (DSLNT) (r = −0.64; P = 0.03), but not for 3-FL, LNFP I, LNFP III, sialyl-LNT (LST) a, LST b, 3′SL and 6′SL.