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The multipotential differentiation abilities of PSCs in vitro and in vivo. PSCs can be induced to differentiate toward insulin-producing cell, adipocyte-like cell, and osteocytes-like cell in vitro. Transplanted PSCs were able to repopulate large areas of the host liver after partial hepatectomy in rats through differentiation into hepatocytes and cholangiocytes in vivo (Mato et al., 2009; Kordes et al., 2012; Zha et al., 2016).
