Table 3.
Adherence to and Acceptability of the Vaginal Ring by Study Arm
| DPV (n = 72) | Placebo (n = 24) | All Arms (N = 96) | |
|---|---|---|---|
| Adherence by self-report | |||
| Week 4 | 58 (80.6%) | 22 (91.7%) | 80 (83.3%) |
| Week 8 | 67 (93.1%) | 22 (91.7%) | 89 (92.7%) |
| Week 12 | 65 (90.3%) | 21 (87.5%) | 86 (89.6%) |
| Median residual DPV levels in VR [IQR] | NA | NA | |
| Week 4 | 21.2 mg [20.8, 21.6] | ||
| Week 8 | 21.1 mg [20.7, 21.5] | ||
| Week 12 | 21.0 mg [20.6, 21.4] | ||
| Overall acceptability of the VRa,b | n = 71 | n = 22 | n = 93 |
| Dislike very much | 0 | 0 | ... |
| Dislike | 6 (8.5%) | 3 (14.6%) | 9 (9.7%) |
| Like | 38 (53.5%) | 12 (54.6%) | 50 (53.8%) |
| Like very much | 27 (38.0%) | 7 (31.8%) | 34 (36.6%) |
| Preference for VR vs condomsb | n = 69 | n = 22 | n = 91 |
| Prefers VR | 42 (60.9%) | 17 (77.3%) | 59 (64.8%) |
| Prefers condoms | 6 (8.7%) | 2 (9.1%) | 8 (8.8%) |
| Likes both | 19 (27.5%) | 3 (13.6%) | 22 (24.2%) |
| Likes neither | 2 (2.9%) | 0 (0%) | 2 (2.2%) |
| Comfort with VRb | n = 72 | n = 22 | n = 94 |
| VR is very easy /easy to use | 71 (98.6%) | 22 (100%) | 93 (98.9%) |
| Is very comfortable /comfortable with VR inside every day | 70 (97.2%) | 21 (95.5%) | 91 (96.8%) |
| Agreed that VR is easy to insert | 62 (86.1%) | 18 (81.8%) | 80 (85.1%) |
| Agreed that VR is easy to remove | 58 (80.6%) | 17 (77.3%) | 75 (79.8%) |
Abbreviations: DPV, dapivirine; IQR, interquartile range; NA, not applicable; VR, vaginal ring.
aMissing 1 answer.
bAsked by computer assisted self-interview at week 12.