Table 1.
Subject characteristics
| Healthy sleepers (N = 19) | OSA | |||
|---|---|---|---|---|
| Chronic OSA (diagnostic) (N = 28) | Treated OSA(CPAP)(N = 28) | Acute OSA(CPAP withdrawal)(N = 24) | ||
| Demographics | ||||
| Age (years) | 33.7 ± 1.6 | 47.3 ± 11.3a | — | 48.5 ± 2.2a |
| Sex | 12M/7F | 21M/7F | 17M/7F | |
| BMI | 25.6 ± 1.1 | 37.9 ± 1.6a | 37.7 ± 1.6a | |
| AHI3A (/hour) | 4.5 ± 3.5 | 67.9 ± 5.4a | 5.4 ± 0.7b | 59.3 ± 4.5a,c |
| Arousal index (/hour) | 13.3 ± 1.3 | 48.6 ± 4.9a | 12.0 ± 1.2b | 36.4 ± 4.9a,c |
| Adherence (hour) | — | — | 4.9 ± 1.7 | — |
| Sleep architecture | ||||
| TST (min) | 440.4 ± 18.3 | 426.5 ± 14.3 | 445.84 ± 11.5 | 423.8 ± 8.3 |
| WASO (%) | 6.8 (5.1) | 15.2 (13.5)a | 10.1 (7.1) | 13.2 (7.3)a |
| SE (%) | 88.5 (6.7) | 83.1 (12.5) | 88.4 (8.1) | 86.6 (8.8) |
| Stage N1 (%) | 16.6 ± 1.2 | 41.4 ± 3.2a | 12.7 ± 0.9b | 35.7 ± 2.7c,a |
| Stage N2 (%) | 49.1 ± 2.0 | 37.2 ± 2.6a | 48.9 ± 1.9b | 44.8 ± 2.0 |
| SWS (%) | 9.1 (8.1) | 4.2 (13.1) | 13.1 (8.4)b | 2.1 (6.3)c |
| REM (%) | 19.2 ± 1.2 | 14.8 ± 1.3a | 21.5 ± 1.1b | 12.4 ± 1.3a,c |
| Daytime sleepiness | ||||
| PVT Lapses | 1.7 (1.5) | 6.1 (7.1)a | 3.7 (2.3)a,b | 6.5 (7.9)a,c |
| ESS | 5.2 ± 0.5 | 13.0 ± 1.0a | 10.7 ± 1.0a | — |
| Mean MSLT (minute) | 10.5 ± 1.1 | 5.5 ± 0.6a | 7.2 ± 0.6a,b | 5.5 ± 0.6a,c |
Normally distributed variables are reported as mean ± SD, whereas non-normally distributed variables are reported as median (interquartile range). SE, sleep efficiency; SWS, slow-wave sleep.
aCompared to healthy sleepers (p < 0.05).
bCompared to chronic OSA (p < 0.05).
cCompared to treated OSA (p < 0.05).