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Graphs showing the (A, B, D) average TCORE and (C, E) TAMBIENT in experiments (A–C) 2 and (D, E) 3. At time 0, the thermostat setting of the environmental chamber remained at 25°C or was increased to 35°C (experiment 2) or 36°C (experiment 3). Experiment 2, n = 8 to 9 mice per group; experiment 3, n = 4 mice per group. *P < 0.01, TCORE in mice exposed to the higher TAMBIENT compared with the low TAMBIENT of 25°C.
