Table 1.
C/EBPβ Interactome Enriched Gene Ontology (GO) Terms
| Enrichment Score | Pathway/Domain Description | Counts in PRISMA | FDR |
|---|---|---|---|
| GO: Biological Processes | |||
| GO:0010467 | Gene expression | 611 | 4.19 × 10−103 |
| GO:0006355 | Regulation of transcription, DNA-templated | 301 | 1.27 × 10−7 |
| GO:0006396 | RNA processing | 267 | 5.63 × 10−128 |
| GO:0007049 | Cell cycle | 211 | 3.06 × 10−31 |
| GO:0008380 | RNA splicing | 172 | 7.14 × 10−106 |
| GO:0051276 | Chromosome organization | 169 | 1.16 × 10−34 |
| GO:0006461 | Protein complex assembly | 128 | 4.17 × 10−12 |
| GO:0016568 | Chromatin modification | 89 | 2.50 × 10−13 |
| GO:0051169 | Nuclear transport | 86 | 9.46 × 10−38 |
| GO:0006281 | DNA repair | 84 | 9.48 × 10−17 |
| GO: Molecular Function | |||
| GO:0003676 | Nucleic acid binding | 745 | 3.8 × 10−199 |
| GO:0003723 | RNA binding | 607 | 0E+00 |
| GO:0005515 | Protein binding | 534 | 1.92 × 10−40 |
| GO:0003677 | DNA binding | 269 | 6.43 × 10−17 |
| GO:0005524 | ATP binding | 216 | 2.82 × 10−24 |
| GO:0003682 | Chromatin binding | 94 | 4.43 × 10−18 |
| GO:0003712 | Transcription cofactor activity | 81 | 2.27 × 10−9 |
| GO:0008134 | Transcription factor binding | 66 | 5.86 × 10−9 |
| GO:0019900 | Kinase binding | 61 | 3.30 × 10−6 |
| GO:0004693 | Cyclin-dependent protein serine/threonine kinase activity | 17 | 6.20 × 10−10 |
| GO: Cellular Component | |||
| GO:0000785 | Chromatin | 103 | 6.04 × 10−31 |
| GO:0005681 | Spliceosomal complex | 85 | 5.10 × 10−56 |
| GO:0005643 | Nuclear pore | 32 | 9.77 × 10−19 |
| GO:0030880 | RNA polymerase complex | 30 | 2.98 × 10−10 |
| GO:0070603 | SWI/SNF superfamily-type complex | 28 | 9.63 × 10−14 |
| GO:0034708 | Methyltransferase complex | 24 | 4.86 × 10−9 |
| GO:0016592 | Mediator complex | 20 | 3.98 × 10−13 |
| GO:0000178 | Exosome (RNase complex) | 12 | 4.26 × 10−9 |
| GO:0016581 | NuRD complex | 11 | 1.50 × 10−9 |
| GO:0016593 | Cdc73/Paf1 complex | 6 | 1.01 × 10−5 |
| Interpro Domains | |||
| IPR027417 | P loop containing nucleoside triphosphate hydrolase | 102 | 9.71 × 10−30 |
| IPR000504 | RNA recognition motif domain | 80 | 8.77 × 10−53 |
| IPR005225 | Small GTP-binding protein domain | 41 | 2.11 × 10−13 |
| IPR016024 | Armadillo-type fold | 34 | 1.69 × 10−11 |
| IPR017986 | WD40-repeat-containing domain | 32 | 6.78 × 10−10 |
| IPR009072 | Histone-fold | 27 | 3.89 × 10−9 |
| IPR001650 | Helicase, C-terminal | 23 | 1.94 × 10−14 |
| IPR011989 | Armadillo-like helical | 21 | 5.11 × 10−6 |
| IPR011545 | DEAD/DEAH box helicase domain | 20 | 2.11 × 10−13 |
| IPR002041 | Ran GTPase | 20 | 5.34 × 10−12 |
| PFAM Domains | |||
| PF00076 | RNA recognition motif. (also called RRM, RBD, or RNP domain) | 72 | 4.32 × 10−49 |
| PF00071 | Ras family | 31 | 8.17 × 10−9 |
| PF00400 | WD domain, G-beta repeat | 29 | 1.38 × 10−10 |
| PF00271 | Helicase-conserved C-terminal domain | 23 | 2.27 × 10−14 |
| PF00125 | Core histone H2A/H2B/H3/H4 | 23 | 1.89 × 10−9 |
| PF00270 | DEAD/DEAH box helicase | 20 | 2.63 × 10−13 |
| PF00013 | KH domain | 10 | 1.36 × 10−6 |
| PF00244 | 14-3-3 protein | 6 | 2.32 × 10−4 |
| PF01423 | LSM domain | 9 | 2.32 × 10−4 |
| PF00538 | Linker histone H1 and H5 family | 5 | 4.50 × 10−4 |