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. Author manuscript; available in PMC: 2020 Mar 28.
Published in final edited form as: J Control Release. 2019 Jan 25;298:27–37. doi: 10.1016/j.jconrel.2019.01.032

Figure 6.

Figure 6.

In vivo intracochlear delivery of sodium salicylate elevated otoacoustic emission thresholds from 8 to 51 kHz in three mice. In each mouse, the cannula was implanted near the round window via a bullaostomy. A) Mean DPOAE threshold shifts from three mice recorded during 20 minutes after the start of a salicylate infusion. DPOAE thresholds systematically increased as a function of perfusion time from the start of the perfusion (0 minutes) to 20 minutes. B) The mean DPOAE threshold shift for the most basal cochlear region, 51 kHz plotted as a function of time following the start of the sodium salicylate infusion. Post 20 and post 40 min denote the measurement times after turning off the pump. PS = post surgery; post 20 = 20 min after stopping infusion; post 40 = 40 min after stopping infusion. SEMs were less than 3 dB for the conditions tested.