Table 1.
Case characteristics for FCTX tissue obtained from brain banks (N=59)
| Characteristic | YC (n=6) | MC (n=12) | OC (n=11) | DS (n=11) | DSAD (n=9) | AD (n=10) |
|---|---|---|---|---|---|---|
| Age at death, y | 17.5 (16.1) | 52.7 (10.4) | 84.5 (5.0) | 20.1 (18.7) | 53.9 (7.4) | 80.6 (8.2) |
| Male/Female (n/n) | 2/4 | 8/4 | 4/7 | 6/5 | 4/5 | 8/2 |
| Post Mortem Interval (PMI), h | 14.0 (7.4) | 14.6 (7.1) | 3.9 (3.1) | 18.7 (9.3) | 8. (7.4) | 5.8 (2.9) |
| Microhemorrhage counts | 0 | 3.3 (6.2) | 2.5 (4.0) | 2.7 (8.4) | 38.4 (45.5) | 33.0 (49.1) |
| CAA Score (n) | ||||||
| 0 – No deposition | 6 | 10 | 9 | 9 | 0 | 1 |
| 1 – Scattered, segmental | 0 | 2 | 1 | 1 | 2 | 4 |
| 2 – Circumferential, ≤ 10 vessels | 0 | 0 | 1 | 1 | 3 | 4 |
| 3 – Widespread, ≤ 75% vessels | 0 | 0 | 0 | 0 | 2 | 0 |
| 4 – Over 75% | 0 | 0 | 0 | 0 | 2 | 1 |
Note: Results presented are mean (SD) unless otherwise noted. YC = young control (control for DS), MC = middle age control (control for DSAD), OC = old control (control for AD), DS = Down syndrome, DSAD = Down syndrome with neuropathological Alzheimer’s disease, AD = sporadic Alzheimer’s disease; CAA = cerebral amyloid angiopathy