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. Author manuscript; available in PMC: 2020 Feb 26.
Published in final edited form as: ACS Nano. 2019 Jan 28;13(2):1272–1283. doi: 10.1021/acsnano.8b06572

Figure 6.

Figure 6

RvD2-nanovesicles inhibit neutrophil infiltration and enhance inflammation resolution in brain tissues. The diagram above shows the experimental protocol. (A) MPO activity in the injured brain at 22 h post-injection of therapeutics (24 h after the MCAO surgery). Treatment with RvD2-HVs and RvD2-NVs was at RvD2 8μg/kg as same as free RvD2. Pro-inflammatory cytokines of TNF-α (B), IL-6 (C) and IL-1β (D) in injured half of brain tissues were measured. All data represent mean ± SD (n=3–6). Two-sample Student’s t test was performed (*p < 0.05, **p < 0.05 and ***p < 0.001).