Table 1.
Functional Annotation of 1,191 Genes Containing TASs within Their First Introns
| Term | Overlap (%) | P |
|---|---|---|
| Gene ontology biological process | ||
| Signal transduction | 6.04 | 1.94E-05 |
| Negative regulation of gene expression | 1.25 | 5.88E-05 |
| Adherens junction organization | 0.60 | 7.99E-05 |
| Negative regulation of cell growth | 0.11 | 8.31E-05 |
| Kidney development | 0.93 | 1.00E-04 |
| KEGG pathway | ||
| HTLV-I infection | 2.02 | 5.50E-05 |
| Inflammatory bowel disease (IBD) | 0.82 | 1.36E-04 |
| Cytokine–cytokine receptor interaction | 1.85 | 2.56E-04 |
| Intestinal immune network for IgA production | 0.65 | 3.80E-04 |
| Pathways in cancer | 2.56 | 5.67E-04 |
| Jensen disease analysis | ||
| Plasma membrane part | 9.57 | 1.03E-14 |
| Spanning component of plasma membrane | 9.15 | 2.41E-13 |
| Extracellular region part | 8.05 | 3.95E-09 |
| Extracellular region | 7.71 | 3.02E-08 |
| Membrane-bounded vesicle | 8.13 | 4.37E-09 |
| MGI mammalian phenotype analysis | ||
| Enlarged spleen | 15.75 | 4.75E-09 |
| Premature death | 9.95 | 2.77E-06 |
| No abnormal phenotype detected | 8.60 | 3.56E-06 |
| Decreased body weight | 9.00 | 1.07E-05 |
| Decreased body size | 9.82 | 1.18E-05 |
Note.—Overlap indicates the proportions of genes carrying TASs in the first intron that overlapped with the genes of each category; P values determined by Fisher’s exact test (i.e., a test of whether the proportion of genes assigned to each category is expected by random chance) were retrieved from DAVID and Enrichr (see Materials and Methods).