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. 2019 Mar 19;2019(3):CD011847. doi: 10.1002/14651858.CD011847.pub2

Lin 2014.

Methods Allocation: parallel, randomised
Blind: not stated
Setting: hospital (inpatient), single centre
Country: China
Length of study: 8 weeks
Participants Diagnosis: treatment‐resistant schizophrenia (ICD‐10)
Total N at randomisation = 78
Sex: male 49, female 29
Age (years): mean 38.25, SD 1.48
Length of illness (years): mean 6.92, SD 1.38
History: poor social function; without history of drug abuse.
Exclusion criteria: patients who are allergic to treatment medications; pregnant women and lactating women; patients with severe chronic illnesses, hypotension, or epilepsy; patients with heart, liver, or kidney dysfunction; patients who do not co‐operate with the treatment; patients with incomplete clinical data.
Interventions ECT group (n = 39): MECT + ziprasidone
Content: the initial dose of ziprasidone was 20 mg/d, increased to 80 mg/d or adjusted according to participant's condition. Participants also received MECT therapy.
Frequency: not stated
Course of treatment (MECT): not stated
Treatment duration: 8 weeks
Control group (n = 39): ziprasidone alone
Content: the usage and dosage of ziprasidone was same as above.
Frequency: not stated
Treatment duration: 8 weeks
Outcomes Mental state: assessed by BPRS
Adverse events
Notes Contact information: Second Department, Fourth People's Hospital of Urumqi, China
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "...were divided randomly into two groups..." (p.202)
Comments: The author described a random component in the sequence generation process, but no details were provided on randomisation method.
Allocation concealment (selection bias) Unclear risk Comments: The author did not describe the allocation concealment. Insufficient information to permit judgement of 'low risk' or 'high risk'.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Comments: The participants and personnel could not be blinded as 1 group did not use ECT, and no sham‐ECT was used.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Comments: The author did not describe the blinding of outcome assessment. Insufficient information to permit judgement of 'low risk' or 'high risk'.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Comments: No missing outcome data.
Selective reporting (reporting bias) Low risk Comments: The protocol is not available; all outcomes stated in methods reported in results.
Other bias Low risk None obvious.