Lin 2014.
Methods |
Allocation: parallel, randomised Blind: not stated Setting: hospital (inpatient), single centre Country: China Length of study: 8 weeks |
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Participants |
Diagnosis: treatment‐resistant schizophrenia (ICD‐10) Total N at randomisation = 78 Sex: male 49, female 29 Age (years): mean 38.25, SD 1.48 Length of illness (years): mean 6.92, SD 1.38 History: poor social function; without history of drug abuse. Exclusion criteria: patients who are allergic to treatment medications; pregnant women and lactating women; patients with severe chronic illnesses, hypotension, or epilepsy; patients with heart, liver, or kidney dysfunction; patients who do not co‐operate with the treatment; patients with incomplete clinical data. |
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Interventions |
ECT group (n = 39): MECT + ziprasidone Content: the initial dose of ziprasidone was 20 mg/d, increased to 80 mg/d or adjusted according to participant's condition. Participants also received MECT therapy. Frequency: not stated Course of treatment (MECT): not stated Treatment duration: 8 weeks Control group (n = 39): ziprasidone alone Content: the usage and dosage of ziprasidone was same as above. Frequency: not stated Treatment duration: 8 weeks |
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Outcomes | Mental state: assessed by BPRS Adverse events |
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Notes | Contact information: Second Department, Fourth People's Hospital of Urumqi, China | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Quote: "...were divided randomly into two groups..." (p.202) Comments: The author described a random component in the sequence generation process, but no details were provided on randomisation method. |
Allocation concealment (selection bias) | Unclear risk | Comments: The author did not describe the allocation concealment. Insufficient information to permit judgement of 'low risk' or 'high risk'. |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Comments: The participants and personnel could not be blinded as 1 group did not use ECT, and no sham‐ECT was used. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Comments: The author did not describe the blinding of outcome assessment. Insufficient information to permit judgement of 'low risk' or 'high risk'. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Comments: No missing outcome data. |
Selective reporting (reporting bias) | Low risk | Comments: The protocol is not available; all outcomes stated in methods reported in results. |
Other bias | Low risk | None obvious. |