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. 2019 Mar;60(3):353–361. doi: 10.2967/jnumed.118.216069

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© 2019 by the Society of Nuclear Medicine and Molecular Imaging.

Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

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FIGURE 6. — (A) Western blot of tumor tissue lysates from control and cetuximab-treated mice demonstrating EGFR protein expression, activation, and downstream signaling. (B) Spearman rank correlation analysis for EGFR expression as determined by Western blot against ¹⁸F-AlF-NOTA-Z_EGFR:03115 tumor uptake as quantified by PET image analysis. Dashed lines represent 95% confidence levels. (C) Histopathologic analysis of EGFR expression and hematoxylin and eosin (H&E) staining in HN5 xenografts in both control and cetuximab-treated mouse. A.U. = arbitrary units.