Table 1.
Demographic, Cognitive, and Pathologic Characteristics of Participants
| Variable | Mean (SD) or N (%) |
|---|---|
| Total Participants | 554 (100%) |
| MAP | 286 (51.6%) |
| ROS | 268 (48.4%) |
| Demographic | |
| Age at Death (years) | 90.4 (6.0) |
| Female | 395 (71.3%) |
| Education (years) | 15.8 (3.6) |
| White, Non-Hispanic | 536 (96.9%) |
| Clinical Diagnosis | |
| Cognitive Impairment at Baseline | |
| Mild Cognitive Impairment (MCI) | 151 (27.3%) |
| Alzheimer’s Disease (AD) | 33 (6.0%) |
| Cognitive Impairment at Death | |
| Mild Cognitive Impairment (MCI) | 143 (26.3%) |
| Alzheimer’s Disease (AD) | 230 (42.4%) |
| Cognitive | |
| Number of Annual Cognitive Evaluations | 9.3 (4.6) |
| Baseline MMSE (score out of 30) | 27.7 (2.8) |
| Proximate to Death MMSE | 20.5 (9.2) |
| Global Cognition, Baseline (composite of 17 z-scores) | −0.07 (0.59) |
| Global Cognition, Proximate to Death | −0.85 (1.11) |
| Global Cognition, Estimated Linear Rate of Change (per year) | −0.10 (0.10) |
| Pathologic | |
| Postmortem Interval (hours) | 8.7 (5.8) |
| Amyloid Load (square root transform) | 2.04 (1.19) |
| Tangles (square root transform) | 2.28 (2.12) |
| Gross Infarcts (present) | 189 (34.1%) |
| Lewy Bodies (present) | 127 (22.9%) |
| Hippocampal sclerosis (present) | 67 (12.1%) |
| TDP-43 (stage 0-3) | 1.11 (1.13) |
| Cerebral amyloid angiopathy (semiquantitative 0-3) | 1.13 (1.05) |
| Atherosclerosis (semiquantitative 0-3) | 1.11 (0.84) |
| Arteriolosclerosis (semiquantitative 0-3) | 1.03 (0.86) |