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Schematic showing the time-staggered delivery of ERL and DOX-containing vesicles from Sequogel. ERL (blue stars) is released in an early time regime, inhibiting EGFR signaling, which sensitizes LN229 glioblastoma cells towards the action of DOX. DOX-loaded vesicles (green) are released slowly in a later time regime. Endocytosed vesicles release DOX (red stars), which enters the nucleus and intercalates within DNA inducing apoptosis.
