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. Author manuscript; available in PMC: 2019 Nov 12.
Published in final edited form as: Angew Chem Int Ed Engl. 2018 Oct 18;57(46):15040–15044. doi: 10.1002/anie.201806483

Figure 2.

Figure 2.

(a) Apoptosis of LN229 cells treated with 10 μM ERL alone for 42 h, 10 μM DOX alone for 18 h, simultaneous delivery of ERL + DOX for 18 h, or sequential administration of ERL→DOX where cells are treated with ERL for 24 h followed by DOX for an additional 18 h. * p˂ 0.05, ** p˂ 0.01. (b) Dose response curves for the different treatment schedules. Dose-dependent (c) Excess Over Bliss (EOB) and (d) Combination Index (CI) values for both simultaneous and sequential delivery of ERL and DOX.