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. Author manuscript; available in PMC: 2019 Nov 12.
Published in final edited form as: Angew Chem Int Ed Engl. 2018 Oct 18;57(46):15040–15044. doi: 10.1002/anie.201806483

Figure 3.

Figure 3.

(a) Schematic diagram showing preparation of Sequogel that comprises of a peptide self-assembling in presence of ERL and DOX-loaded vesicles. (b) Percent DOX released from 1 wt% peptide gel containing negatively charged (POPS/PC/cholesterol), positively charged (DOTAP/PC/cholesterol), and neutral (PC/cholesterol) vesicles. (c) Cryo-TEM of Sequogel containing DOX-vesicles encapsulated within the peptide hydrogel fibrillar network. Inset shows measured fibril widths (n=30). (d) Time-sweep oscillatory rheology of Sequogel and peptide gel alone employing an angular frequency of 6 rad/s and a 0.2 % strain. After initial gelation, gels were shear-thinned at 1000% strain for 30 s and allowed to recover by reducing the strain to 0.2% during the next 1 h. (e) Cumulative release of ERL and DOX from Sequogel over a prolonged period into an infinite sink (25 mM HEPES, 150 mM NaCl, pH 7.4) at 37 °C.