Table 2.

Univariate analysis and incidence rates per 1,000 person-years for ischemic stroke, thrombotic stroke and embolic stroke in participants without atrial fibrillation,^† Atherosclerosis Risk in Communities Study, (1996-2005)

		Ischemic stroke		Thrombotic stroke‡		Embolic stroke‡
Events within 10 yrs		280		146		57
Incidence rates		2.8		1.5		0.58
Individual predictors	Incidence	HR (95% CI)	Incidence	HR (95% CI)	Incidence	HR (95% CI)
Age ≥75§	--	--	--	--	--	--
Age 65-74 vs. <65	4.3	2.22(1.75-2.81)	2.1	1.89(1.37-2.62)	1.0	3.13 (1.82-5.39)
Male vs. female sex	3.5	1.48(1.17-1.87)	1.8	1.52(1.10-2.11)	0.55	0.92(0.54-1.56)
Heart failure	6.2	2.29(1.51-3.48)	1.8	1.24(0.58-2.65)	2.3	4.59 (2.25-9.36)
Hypertension	4.2	2.42(1.89-3.11)	1.9	1.78(1.28-2.48)	0.91	3.09(1.73-5.51)
Hyperlipidemia	2.9	1.04(0.82-1.32)	1.6	1.15 (0.83-1.60)	0.44	0.61 (0.37-1.03)
Diabetes mellitus	6.0	2.64 (2.05-3.40)	3.2	2.71 (1.91-3.83)	1.2	2.62(1.50-4.59)
Vascular disease	6.7	2.68 (1.97-3.65)	2.7	2.02(1.26-3.24)	1.1	2.07 (0.98-4.37)
Aspirin	3.3	1.54(1.20-1.97)	1.6	1.29(0.93-1.80)	0.63	1.28 (0.75-2.18)
Statin use	3.3	1.18(0.83-1.69)	1.7	1.17(0.71-1.91)	0.37	0.61 (0.22-1.69)
CHA2DS2-VASc
0-1 reference	1.3	1 (ref)	0.91	1 (ref)	0.15	1 (ref)
2	3.3	2.54 (1.85-3.49)	1.6	1.71 (1.13-2.59)	0.72	4.91 (2.10-11.5)
3	5.0	3.80 (2.73-5.28)	2.6	2.92(1.91-4.45)	1.0	7.07 (2.93-17.0)
4	6.8	5.16 (3.30-8.06)	2.9	3.22(1.70-6.11)	2.2	14.8(5.50-39.6)
≥5	8.9	6.84 (3.27-14.3)	1.1	1.25 (0.17-9.09)	2.2	15.2(3.16-73.3)
Abbreviations: HR, hazard ratios

^†Excluding and censoring anticoagulant use at baseline and follow up

^‡Incidence rates for thrombotic and embolic stroke includes “definite” stroke only; ischemic stroke incidence includes “definite” as well as “probable” stroke.

^§Insufficient data (only 1 patient was aged ≥75 at baseline)