Table 3.

Incidence rates per 1,000 person-years for ischemic stroke in participants without AF based on CHA₂DS₂-VASc risk score at 1 year, 5 years, and 10 years of follow-up,^† Atherosclerosis Risk in Communities Study

	CHA₂DS₂-VASc score
	0-1	2	3	4	≥5
No AF, Number of participants	4976	3282	1800	498	115
1 Year of follow-up
# of Ischemic stroke events	4	13	5	6	4
Person-years	4959	3266	1790	489	114
Incidence rate (95% CI)	0.81 (0.27-1.92)	3.98 (2.23-6.61)	2.79 (1.06-6.12)	12.3 (5.10-25.3)	35.1 (11.7-83.4)
5 Years of follow-up
# of Ischemic stroke events	29	57	38	15	6
Person-years	24407	15874	8660	2299	523
Incidence rate (95% Cl)	1.19 (0.81-1.68)	3.59 (2.75-4.62)	4.39 (3.15-5.96)	6.52 (3.81-10.5)	11.5 (4.8-23.6)
10 Years of follow-up
# of Ischemic stroke events	62	101	81	28	8
Person-years	47370	30351	16310	4151	897
Incidence rate (95% CI)^‡	1.31 (1.01-1.67)	3.33 (2.73-4.03)	4.97 (3.97-6.14)	6.75 (4.58-9.61)	8.9(4.20-16.8)
Abbreviations: AF, atrial fibrillation; CI, confidence interval.

^†

Excluding and censoring anticoagulant use at baseline and follow up

^‡

The data in this row was also reported in Table 2

The p-value for trend of the CHA₂DS₂-VASc score for ischemic stroke was <0.0001 for the 1, 5, and 10 year follow-up years