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. Author manuscript; available in PMC: 2019 Mar 19.
Published in final edited form as: Cell Rep. 2019 Mar 12;26(11):2890–2903.e3. doi: 10.1016/j.celrep.2019.01.116

Figure 6. Pc Loops Are Independent of Transcription, Cohesin, and Condensin II.

Figure 6.

(A) Hi-C heatmap showing a strong loop identified using Hi-C computational unbiased peak search (HiCCUPS; arrowhead). Cap-H2, Rad21, RNAPII, and Pc ChIP-seq tracks are shown. The eigenvector showing A and B compartmental domains is also shown.

(B) Metaplot of Hi-C signal in control WT compared to Rad21 knockdown (Rad21 KD), cells treated with flavopiridol (FLV), and Cap-H2 knockdown (Cap-H2 KD). Signal score (APA) is calculated based on Hi-C strength of the center pixel versus the background (a 3 × 3 grid in the top right corner).