Fig 2. Δ346 virus is attenuated in IFNAGR^-/- mice.

(A-B) IFNAGR^-/- mice were infected with 10³ FFU of WT or Δ346 ZIKV via footpad infection and monitored for (A) survival and (B) weight loss (n = 13 for each group). (C-D) Mice were infected with 10³ or 10⁴ FFU Δ346 ZIKV via footpad infection and monitored for (C) survival and (D) weight loss (n = 13 and 4, respectively). Log-rank test was conducted on survival curves. * represents p < 0.05. ‘ns’ represents not statistically significant. Dotted line represents 100% starting weight. Error bars represent standard error of the mean.