Fig 3. Δ346 mutant is attenuated early but reaches similar end point titers in immunocompromised mice.
IFNAGR-/- mice were infected with 103 FFU of WT or Δ346 ZIKV via footpad infection. On day six post infection, (A) serum, liver, spleen, kidney, (B) spinal cord, and brain were harvested and titered for infectious virus levels (n = 7 WT and n = 6 Δ346 ZIKV infected mice). Moribund mice were harvested for (C) serum, spinal cord, and brain end-point titer analysis (n = 4 for each group). Mann-Whitney tests were performed on log-transformed data. * represents p < 0.05. Dotted line represents limit of detection. Data points not detected are plotted at half the limit of detection. Error bars represent standard deviation.