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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Transl Res. 2018 Jun 23;201:136–153. doi: 10.1016/j.trsl.2018.05.007

Figure 1. Visual schematic of the EWS-Ets fusion gene.

Figure 1.

(A) The EWS-Ets rearrangement is caused by the fusion of the N-terminal transactivation domain of the EWSR1 gene with the C-terminal DNA binding domain of a select member of the Ets gene family. (B) Approximately 90% or more of ETW-Ets fusions involve the FLI1 gene. ERG is the next most common fusion partner accounting for between 5 and 10 % of cases. Rarely, EWS has been observed to be paired with ETV1, ETV5, and FEV1, and these fusions account for less than 1% of total cases.