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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Prostate. 2018 Jul 15;78(15):1140–1156. doi: 10.1002/pros.23689

Figure 5. The E1A12 266 aa variant bridges the AR N/C interaction.

Figure 5.

(A) The AR LBD (690–919) was fused to the Gal4-BD and the AR NTD (1–566) was attached to the VP16 activation domain. The luciferase reporter used in Fig. 1 along with a sea pansy (Renilla) luciferase reporter were cotransfected with the indicated plasmids into Saos-2 cells. Dual luciferase assays were conducted as in Fig. 1. Shown are average values along with SEM of three experiments. The P values were calculated based on Student’s t test. The expression of the transfected constructs is detected in a Western blot (lower panels). (B) A cartoon showing an E1A12 266aa-mediated AR NTD-LBD interaction.