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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Neurobiol Dis. 2018 Sep 10;121:65–75. doi: 10.1016/j.nbd.2018.09.002

Figure 4. Tadalafil prevents ON axon depletion in WT and GC-1−/− mice in the murine POAG model of glaucoma.

Figure 4.

A) Representative paraphenylenediamine -stained ON axon micrographs in WT and GC-1−/− mice maintained on control or tadalafil chow, scale bar = 10μM. B) Quantitative analysis of the mean density of RGC axons (y-axis; mean axons/mm2 ± S.D) in optic nerve reveals decreased RGC axon density in GC-1−/− mice that is reversed by tadalafil treatmern ***, p<0.0001.