Table 2.
Ocular localization of nitric oxide synthase (NOS) and soluble guanylate cyclase (GC-1).
| Gene/isoform | Species | Site of expression (cell or tissue) | Reference |
|---|---|---|---|
| NOS1 (nNOS) | Human | Ciliary non-pigmented epithelium | [51] |
| Human | ONH astrocytes, lamina cribrose | [44] | |
| Monkey | Amacrine cells, rod and cone photoreceptors, RGC | [56] | |
| Canine | RGC | [57] | |
| Rabbit | Amacrine cells, rod and cone photoreceptors, RGC | [56] | |
| Rat | Ciliary process epithelium, INL, IPL, RGC layer, photoreceptors | [52,63] | |
| Murine | Retinal amacrine cells | [58] | |
| Murine | Retinal amacrine cells, RGC layer somata; IPL puncta | [59] | |
| Murine | Müller cells | [60] | |
| Guinea pig | RGC layer, INL, IPL | [61] | |
| Chicken | RGC layer, INP, IPL | [62] | |
| NOS2 (iNOS) | Human | Macrophages in stroma and ciliary processes | [46] |
| Human | Astrocytes | [64] | |
| Chicken | RPE | [62] | |
| NOS3 (eNOS) |
Human | Longitudinal CM fibers, TM, SC | [46] |
| Human | Retinal vasculature | [44] | |
| Human | TM | [47] | |
| GC-1 | Human | RGC, IPL, ONL | [66] |
| Human | TM cells | [67] | |
| Rabbit | Amacrine cells, bipolar cells, cone photoreceptors, RGC | [56] | |
| Murine | Somata in the INL, ONL, IPL, and OPL | [59] | |
| Murine | RGC, IPL, ONL | [66] | |
| Turtle | Amacrine cells, bipolar cells, RGC layer, IPL | [69] | |
ONH, optic nerve head; RGC, retinal ganglion cell; IPL, inner plexiform layer; CM, ciliary muscle; TM, trabecular meshwork; SC, Schlemm’s canal; ONL, outer nuclear layer; INL, inner nuclear layer; OPL, outer plexiform layer.