TABLE 2:

Pharmacotherapy Studies in the Prevention of Postpartum Depression

Study	Design	Study duration	Intervention	Total sample size	Summary of findings
Wisner et al. (2001)[86]	Randomized clinical trial	20 weeks	Nortriptyline, placebo	56	No significant differences were detected in rates of recurrence or time to relapse between women receiving nortriptyline and women receiving placebo.
Wisner et al. (2004) [88]	Randomized clinical trial	17 weeks	Sertraline, placebo	25	Treatment with sertraline was associated with fewer depressive relapses and a significantly longer time to relapse.
Yonkers et al.(2011) [218]	Prospective cohort	variable	Various	778	There was no clear difference in risk of a depressive episode in pregnancy between women who took antidepressants and women who did not.
Khazaie et al. (2013) [89]	Randomized clinical trial	6 weeks	Diphenhydraminemine, trazodone, placebo	54	Both diphenhydramine and trazodone were effective in preventing postpartum depressive symptoms at 2 and 6 weeks after delivery. No differences in depressive symptoms were observed between the trazodone and diphenhydramine groups.
Xu et al. (2017) [219]	Randomized clinical trial	6 weeks	Single intra-operative low-dose intravenous ketamine, placebo	330	No significant differences were detected in the prevalence of PPD between the two groups at 3 days and 6 weeks post-delivery.