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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: J Immunol. 2019 Feb 11;202(7):2017–2026. doi: 10.4049/jimmunol.1801436

Figure 1. Anti-TNFα and Anti-IL17A antibodies inhibit disease progression in collagen-induced arthritis.

Figure 1.

(A) Top: study design. Middle: Average paw CIA score over the indicated times. Bottom: Area Under the Curve (AUC). Data were transformed using the Huber M transform, followed by one-way ANOVA with Dunnett’s post-testing, presented as mean + SEM (n = 8–12). *** P<0.005, ** <0.01; Dex = dexamethasone. (B) Protein or mRNA expression of inflammatory genes in front paws were measured on day 39 using Luminex. Relative expression of different proteins or mRNAs are normalized to the naïve animal group, Log2 transformed and plotted as a Heatmap. Each row represents one gene and each column represents one mouse.