Table 1:

Detailed Search Strategy: Two independent reviewers (CVT and SZ) conducted a literature search in PubMed and Excerpta Medica Database (EMBASE) using a hierarchical search strategy. Medical subject headings (MeSH) were used for the PubMed query. The literature search was limited to full-text manuscripts written in English and published in peer-reviewed journals before 31 December 2017.

PubMed

Search Items	Results
“tomography, optical coherence”[MeSH Terms] AND “dementia”[MeSH Terms]	58
“tomography, optical coherence”[MeSH Terms] AND “cognitive dysfunction”[MeSH Terms]	10
“tomography, optical coherence”[MeSH Terms] AND “neurobehavioral manifestations”[MeSH Terms]	35
“tomography, optical coherence”[MeSH Terms] AND “alzheimer disease”[MeSH Terms]	48
(“tomography, optical coherence”[MeSH Terms] OR (“tomography”[All Fields] AND “optical”[All Fields] AND “coherence”[All Fields]) OR “optical coherence tomography”[All Fields] OR (“optical”[All Fields] AND “coherence”[All Fields] AND “tomography”[All Fields])) AND (“dementia”[MeSH Terms] OR “dementia”[All Fields])	93
(“tomography, optical coherence”[MeSH Terms] OR (“tomography”[All Fields] AND “optical”[All Fields] AND “coherence”[All Fields]) OR “optical coherence tomography”[All Fields] OR (“optical”[All Fields] AND “coherence”[All Fields] AND “tomography”[All Fields])) AND (“alzheimer disease”[MeSH Terms] OR (“alzheimer”[All Fields] AND “disease”[All Fields]) OR “alzheimer disease”[All Fields] OR “alzheimer”[All Fields])	76
(“tomography, optical coherence”[MeSH Terms] OR (“tomography”[All Fields] AND “optical”[All Fields] AND “coherence”[All Fields]) OR “optical coherence tomography”[All Fields] OR (“optical”[All Fields] AND “coherence”[All Fields] AND “tomography”[All Fields])) AND (“cognitive dysfunction”[MeSH Terms] OR (“cognitive”[All Fields] AND “dysfunction”[All Fields]) OR “cognitive dysfunction”[All Fields] OR (“cognitive”[All Fields] AND “impairment”[All Fields]) OR “cognitive impairment”[All Fields])	62
(“tomography, optical coherence”[MeSH Terms] OR (“tomography”[All Fields] AND “optical”[All Fields] AND “coherence”[All Fields]) OR “optical coherence tomography”[All Fields] OR (“optical”[All Fields] AND “coherence”[All Fields] AND “tomography”[All Fields])) AND (“cognitive dysfunction”[MeSH Terms] OR (“cognitive”[All Fields] AND “dysfunction”[All Fields]) OR “cognitive dysfunction”[All Fields] OR (“cognitive”[All Fields] AND “decline”[All Fields]) OR “cognitive decline”[All Fields])	34
(Spectral[All Fields] AND (“protein domains”[MeSH Terms] OR (“protein”[All Fields] AND “domains”[All Fields]) OR “protein domains”[All Fields] OR “domain”[All Fields])) AND (“dementia”[MeSH Terms] OR “dementia”[All Fields])	50
(Spectral[All Fields] AND (“protein domains”[MeSH Terms] OR (“protein”[All Fields] AND “domains”[All Fields]) OR “protein domains”[All Fields] OR “domain”[All Fields])) AND (“alzheimer disease”[MeSH Terms] OR (“alzheimer”[All Fields] AND “disease”[All Fields]) OR “alzheimer disease”[All Fields] OR “alzheimer”[All Fields])	36
(Spectral[All Fields] AND (“protein domains”[MeSH Terms] OR (“protein”[All Fields] AND “domains”[All Fields]) OR “protein domains”[All Fields] OR “domain”[All Fields])) AND (“cognitive dysfunction”[MeSH Terms] OR (“cognitive”[All Fields] AND “dysfunction”[All Fields]) OR “cognitive dysfunction”[All Fields] OR (“cognitive”[All Fields] AND “impairment”[All Fields]) OR “cognitive impairment”[All Fields])	25
(Spectral[All Fields] AND (“protein domains”[MeSH Terms] OR (“protein”[All Fields] AND “domains”[All Fields]) OR “protein domains”[All Fields] OR “domain”[All Fields])) AND (“cognitive dysfunction”[MeSH Terms] OR (“cognitive”[All Fields] AND “dysfunction”[All Fields]) OR “cognitive dysfunction”[All Fields] OR (“cognitive”[All Fields] AND “decline”[All Fields]) OR “cognitive decline”[All Fields])	20
Total:	547

Excerpta Medica Database (EMBASE)

Search Items	Results
(Optical Coherence Tomography and Dementia).af.	130
(Optical Coherence Tomography and Alzheimer).af.	235
(Optical Coherence Tomography and Cognitive Dysfunction).af.	12
(Optical Coherence Tomography and Cognitive Impairment).af.	112
(Optical Coherence Tomography and Cognitive Decline).af.	29
(Spectral Domain and Dementia).af.	47
(Spectral Domain and Alzheimer).af.	79
(Spectral Domain and Cognitive Dysfunction).af.	4
(Spectral Domain and Cognitive Impairment).af.	34
(Spectral Domain and Cognitive Decline).af.	15
Total:	697