Table 6: Sub-Group Analyses based on the Method of Eye Selection.

Studies with single-eye dataset selected SD-OCT measurements from either eye of each study subject, while studies with paired-eyes dataset selected SD-OCT measurements from both eyes of each study subject.

	All Eligible Studies		Studies with Single-Eye Dataset		Studies with Paired-Eyes Dataset
	SMD [95% CI]	WMD [95% CI]	SMD [95% CI]	WMD [95% CI]	SMD [95% CI]	WMD [95% CI]
Mean GC-IPL
AD vs Controls	−0.46 [−0.80, −0.11] *	−3.66 [−6.49, −0.83] *	−0.52 [−0.83, −0.21] **	−4.48 [−7.50, −1.45] *	−0.30 [−1.38, 0.79]	−1.96 [−9.75, 5.84]
MCI vs Controls	−0.57 [−1.38, 0.24]	−10.19 [−20.42, 0.05]	−0.95 [−1.79, −0.10] *	−18.49 [−32.05, −4.92] *	0.61 [0.06, 1.17]	5.10 [0.63, 9.57]
Mean RNFL
AD vs Controls	−0.70 [−0.99, −0.40] **	−6.24 [−9.21, −3.26] **	−0.71 [−1.04, −0.39] **	−6.70 [−10.26, −3.14] **	−0.81 [−1.53, −0.09] *	−5.81 [−11.55, −0.07] *
MCI vs Controls	−0.25 [−0.68, 0.18]	−2.39 [−6.34, 1.57]	−0.09 [−0.42, 0.24]	−0.97 [−4.17, 2.22]	−0.48 [−1.50, 0.54]	−3.70 [−11.63, 4.23]
Macular Volume
AD vs Controls	−0.58 [−1.03, −0.14] *	−0.23 [−0.35, −0.10] **	−0.50 [−0.80, −0.20] *	−0.24 [−0.35, −0.14] **	−0.78 [−2.69, 1.13]	−0.14 [−0.57, 0.29]
MCI vs Controls	−0.21 [−0.67, 0.25]	−0.10 [−0.31, 0.11]	−0.07 [−0.48, 0.33]	−0.04 [−0.25, 0.18]	−0.36 [−1.43, 0.72]	−0.13 [−0.55, 0.29]
Macular Thickness (AD vs Controls)
Foveal	−0.18 [−0.36, 0.00]	−4.38 [−8.95, 0.18]	−0.14 [−0.37, 0.09]	−3.01 [−7.31, 1.29]	−0.49 [−1.38, 0.40]	−12.75 [−36.80, 11.29]
Inner Superior	−0.62 [−0.86, −0.38] **	−12.85 [−17.55, −8.14] **	−0.54 [−0.71, −0.37] **	−10.92 [−14.92, −6.92] **	−0.81 [−1.84, 0.21]	−16.78 [−31.26, −2.30] *
Inner Nasal	−0.55 [−0.82, −0.29] **	−10.45 [−15.55, −5.36] **	−0.44 [−0.65, −0.24] **	−8.35 [−11.77, −4.92] **	−0.84 [−1.93, 0.25]	−15.76 [−36.21, 4.69]
Inner Inferior	−0.74 [−1.07, −0.41] **	−14.56 [−21.03, −8.09] **	−0.69 [−0.99, −0.39] **	−13.65 [−19.53, −7.78] **	−0.90 [−2.20, 0.41]	−17.24 [−41.87, 7.39]
Inner Temporal	−0.58 [−0.81, −0.35] **	−10.84 [−14.93, −6.74] **	−0.49 [−0.65, −0.33] **	−9.28 [−12.12, −6.44] **	−0.82 [−1.87, 0.23]	−14.54 [−32.09, 3.01]
Outer Superior	−0.65 [−0.91, −0.40] **	−11.59 [−16.23, −6.96] **	−0.76 [−0.98, −0.55] **	−13.82 [−17.10, −10.53] **	−0.38 [−0.95, 0.20]	−6.56 [−17.00, 3.88]
Outer Nasal	−0.70 [−1.04, −0.36] **	−12.59 [−19.15, −6.02] **	−0.59 [−0.85, −0.32] **	−10.45 [−14.99, −5.91] **	−1.02 [−2.52, 0.48]	−18.84 [−48.04, 10.37]
Outer Inferior	−0.52 [−0.74, −0.30] **	−9.71 [−14.11, −5.30] **	−0.60 [−0.86, −0.35] **	−11.28 [−16.53, −6.03] **	−0.28 [−0.53, −0.04] *	−5.10 [−9.84, −0.35] *
Outer Temporal	−0.57 [−0.75, −0.39] **	−10.24 [−13.40, −7.08] **	−0.62 [−0.78, −0.46] **	−11.16 [−13.82, −8.50] **	−0.50 [−1.10, 0.10]	−8.20 [−17.86, 1.46]

Abbreviations: SMD = Standardized mean difference; WMD = Weighted mean difference; GC-IPL = Ganglion cell-inner plexiform layer; RNFL = Retinal nerve fibre layer;

^*= p<0.05;

^**= p<0.001