Table 1. Sufficient-component cause model for mortality stratified per ARDS phenotype. Prevalence hypo-inflammatory: 65% and hyper-inflammatory: 35% (12).
| Phenotype | Outcome if exposed to | Individual causal effect | Type | Proportion of total | ||
|---|---|---|---|---|---|---|
| Placebo | Drug | HARP-2 | Enrichment hyper-inflammatory | |||
| Hypo-inflammatory | 1 | 1 | 1−1=0 | Doomed | 0.10 | – |
| Hyper-inflammatory | 1 | 1 | 1−1=0 | Doomed | 0.11 | 0.32 |
| Hypo-inflammatory | 1 | 0 | 1−0=1 | Benefit | 0 | – |
| Hyper-inflammatory | 1 | 0 | 1−0=1 | Benefit | 0.05 | 0.13 |
| Hypo-inflammatory | 0 | 1 | 0−1=−1 | Harmed | 0.01 | – |
| Hyper-inflammatory | 0 | 1 | 0−1=−1 | Harmed | 0 | 0 |
| Hypo-inflammatory | 0 | 0 | 0−0=0 | Immune | 0.54 | – |
| Hyper-inflammatory | 0 | 0 | 0−0=0 | Immune | 0.19 | 0.55 |