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. 2019 Mar 6;101(5):905–919.e8. doi: 10.1016/j.neuron.2019.01.047

Figure 2.

Figure 2

CIP Mutations Result in Loss of NaV1.7 Function

(A) Schematic of NaV1.7 channel topology. CIP mutations are represented with orange dots.

(B) Representative currents elicited by a test potential to −10 mV from a holding potential of −100 mV for the wild-type (WT) (black), G1725R (red), or FS1773 (blue) channels.

(C) Summarized data for whole-cell current density elicited by a test potential to −10 mV from a holding potential of −100 mV for the WT (−474.2 ± 75 pA/pF, n = 17), R896W (−7.6 ± 3.8 pA/pF, n = 9), R830X (−2.8. ± 0.9 pA/pF, n = 8), G1725R (−15.7 ± 5.4 pA/pF, n = 9), and FS1773 (−62.2 ± 18.8, n = 8). Data are presented as mean ± SEM. For all, ∗∗∗∗p ≤ 0.0001 compared with WT. One-way ANOVA followed by Dunn’s multiple comparison test.