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. 2019 Mar 13;10:378. doi: 10.3389/fimmu.2019.00378

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Copyright © 2019 Iliev, Lagos, Thim, Jørgensen, Krasnov and Jørgensen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Salmon MPs develop dendritic morphology following prolonged treatment with CpGs. (A) Images of non-stimulated MPs and cells stimulated for 7 days with 2 μM CpGs and 20 μg/ml of polyI:C. The arrow indicates a typical DC-like cell observed in the CpG-treated samples. (B) Dynamic reorganization of the morphology of CpG-treated MPs. Cells were stimulated as in panel A and images were taken at 30min intervals over a period of 90min. The arrow points at elongated DC-like cell which changes morphology into a more rounded macrophage-like cell. The arrowhead indicates a cell which undergoes the opposite changes. Images were taken at X200 magnification.