Table 3.
Differences to baseline in disease specific data, indices of aerobic fitness, and heart rate data after a 12-week moderate-intensity aerobic training in patients without (SZ-nonCI) and with (SZ-CI) chronotropic incompetence.
| Training nonCI-patients | Training CI-patients | |
|---|---|---|
| n = 16 | n = 6 | |
| EPIDEMIOLOGICAL DATA | ||
| Body mass; kg | −0.9 ± 5.2 | −0.5 ± 9.1 |
| BMI; kg/m2 | −0.2 ± 1.6 | 0.0 ± 2.6 |
| DISEASE SPECIFIC DATA | ||
| PANSS | −8.9 ± 18.6* | 7.0 ± 13.5 |
| MEDICATION | ||
| Chlorpromazine equivalents, CPE (mg/d) | −2 ± 473 | 212 ± 552 |
| PARAMETERS OF AEROBIC FITNESS BEFORE AND AFTER TRAINING | ||
| Peak oxygen uptake; ml/kg/min | 1.52 ± 5.24 | 0.45 ± 5.42 |
| Peak oxygen uptake; % pred | 4.8 ± 15.7 | 2.0 ± 16.0 |
| Peak power output; W/kg | 0.18 ± 0.23*# | 0.09 ± 0.43 |
| PWC 130; W/kg (non CI: n = 15, CI: n = 5) | 0.20 ± 0.26*# | −0.00 ± 0.37 |
| PWC 150; W/kg (CI: n = 5) | 0.22 ± 0.26*# | 0.08 ± 0.43 |
| Power output at Lactate Threshold; W/kg | −0.02 ± 0.32 | 0.05 ± 0.24 |
| OBJECTIVE EFFORT | ||
| Peak blood lactate; mmol/l | 0.83 ± 1.66 | 0.83 ± 2.83 |
| HEART RATE DATA AND CHRONOTROPIC RESPONSE | ||
| Baseline heart rate; 1/min | −4.7 ± 13.4 | −6.1 ± 7.1 |
| Peak heart rate; 1/min | 0.0 ± 10.4 | −0.5 ± 18.8 |
| % pred. heart rate reserve | 0.1 ± 13.1 | 3.4 ± 17.0 |
| Slope metabolic-chronotropic relationship | 0.01 ± 0.14 | 0.02 ± 0.20 |
Data are shown as mean ± standard deviation.
n = number of participants if not all are include in calculation because of excluded or missing data (e.g., failure to reach a given heart rate),
* and #
indicates statistically significant difference from baseline values, P < 0.05 (*not adjusted/*#adjusted for multiple testing).
Bold values indicate significant differences before and after training within a group.