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. 2019 Mar 13;10:199. doi: 10.3389/fphar.2019.00199

Figure 3.

Figure 3

Prophylactic efficacy of EFV against the wild-type and resistant virus using different prophylaxis schemes. (A) Predicted prophylactic efficacies for once daily 400 mg oral EFV PrEP with different levels of adherence. For example in the 25% adherence scheme, each dosing event was randomly missed with 75% chance. Colored dots mark the median predicted prophylactic efficacy and error bars mark the 95% confidence interval (computed using Greenwood's formula), considering variabilities in pharmacokinetic, as well as pharmacodynamic parameters. (B) Predicted prophylactic efficacy of 400 mg oral EFV during “PrEP on demand” (3 doses) depending on the time of PrEP initiation with respect to viral encounter, respectively. (C) Predicted prophylactic efficacy of post-exposure prophylaxis (9 doses) with 400 mg oral EFV as a function of the time of PEP initiation after viral challenge. Simulations were conducted using the hybrid EXTRANDE method outlined in the Methods section. In total, 10,000 stochastic simulations were performed to estimate prophylactic efficacy for each condition (e.g., viral challenge with K103N during chronic PrEP with 5% adherence is one condition).