Table 1.

Pharmacokinetic parameters.

Parameter	Value	Unit	Parameter	Value	Unit
CLss/Fbio	11.9	L/h	V/Fbio	282	L
α	0.58	–	σ	0.20	–
CVIIV(CLss/Fbio)	36.6	%	CVIOV(CLss/Fbio)	21.0	%

The table displays the pharmacokinetic parameter estimates for a 70 kg individual with reference genotype (reference: CYP2B6, pos. 516:GG, pos. 516:TT and for CYP2A ^*9B and ^*17: CC/CC or CC/CT or CC/TT or CA/CC or CA/CT or AA/CC or AA/CT Dickinson et al., 2015). Inter-individual variability (IIV), as well as inter-occasional variability (IOV) was included on drug clearance CL/F_bio. These parameters were log-normal distributed with coefficient of variation [%] $CV=100·\sqrt{e^{{\sigma }^2}-1}$, where σ² is the variance of the associated normal distribution. Weight was considered to affect $\text{C}{\text{L}}_{ss}(i)/F_{\text{bio}}=\text{C}{\text{L}}_{ss}/F_{\text{bio}}·{(\text{weight}(i)/70)}^{0.75}$ and the volume of distribution V(i)/F_bio = V/F_bio·(weight(i)/70) through allometric scaling. Residual variability was described by a proportional error model (σ = 0.2).