Table 2.

Pharmacodynamic parameters.

Strain	IC50 (± sd)	m (± sd)	f
wild type	5.4 (± 0.9)	1.69 (±0.08)	1
Y181C	2.8·IC50(wt)	0.9·m(wt)	0.78
K103N	89.1·IC50(wt)	0.83·m(wt)	0.74
G190S	72.1·IC50(wt)	0.6·m(wt)	0.24

The table displays the pharmacodynamic parameters for wild type (Shen et al., 2008) and different viral mutants (Sampah et al., 2011). The hill coefficient m (unit less) was assumed to be normal distributed and IC₅₀ values (nmol/L) were assumed to be log-normal distributed (Jilek et al., 2012). Parameters were corrected for protein binding as outlined in Supplementary Text 1. Parameter f (unit less) denotes the fitness of the respective strains. The respective parameter distributions for the mutants (IC₅₀, m) were computed by assuming an identical coefficient of variation as compared to the wild type.