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. 2018 Jun 22;94(9):fiy125. doi: 10.1093/femsec/fiy125

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© FEMS 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Metabolic pathways from tyrosine to phenol and p-cresol

Metabolic pathways from tyrosine to phenol (A, B) and p-cresol (C, D) are shown as indicated by previous reports (Enei et al.1973; Gelfand and Steinberg 1977; Kriek et al.2007; Windey, De Preter and Verbeke 2012; Dodd et al.2017). Known enzymes—tyrosine phenol-lyase (TPL), tyrosine aminotransferase B (TyrB), phenyllactate dehydrogenase (FldH), phenyllactate dehydratase (FldBC), acyl-CoA dehydrogenase (AcdA), hydroxyarylic acid decarboxylase (Had), tyrosine lyase (ThiH), pyruvate:ferredoxin oxidoreductase A (PorA) and hydroxyphenylacetate decarboxylase (Hpd)—are shown near the arrows for each step. Steps with unidentified enzymes are indicated by dotted lines. Compounds used in this study are marked with asterisks.