. 2019 Mar 13;10:410. doi: 10.3389/fimmu.2019.00410

Table 1.

Murine and human dendritic cell subsets are outlined with their surface phenotype, major transcription factors required for their development and their main functions (7–11).

		Surface maker					Specific transcription factors	Common function
DC subset		Murine			Human		Specific transcription factors	Antigen presentation and cytokine production	Downstream effect
cDC	cDC1	CD11c^hi, MHC-II⁺, CD45RA⁻, Siglec H⁻, PCDA-1⁻	XCR1⁺, Clec9A⁺, DEC205⁺	CD8α⁺ (lymphoid tissues)	HLA-DR⁺, CD11c⁺, CD123⁻	XCR1⁺, CD141⁺, Clec9A⁺	Irf8, Id2, Batf3	Direct and cross-presentation IL-12, IL-6, Type III IFN	CD8⁺ T cell activation Th1 activation
	cDC1		XCR1⁺, Clec9A⁺, DEC205⁺	CD103⁺ (non-lymphoid tissues)		XCR1⁺, CD141⁺, Clec9A⁺	Irf8, Id2, Batf3	Direct and cross-presentation IL-12, IL-6, Type III IFN	CD8⁺ T cell activation Th1 activation
	cDC2		Sirpα⁺, CD11b⁺	Esam^hi, CD4⁺, Clec4a4⁺ (lymphoid tissues)		Sirpα⁺, CD1c⁺, CD301⁺	Irf4, Notch2, Klf4	Direct presentation IL-6, TNF-α IL-23 (intestinal and lung)	Th2 and Th17 activation
	cDC2		Sirpα⁺, CD11b⁺	Esam^lo, Clec12A⁺, CD103^+/− (non-lymphoid tissues)		Sirpα⁺, CD1c⁺, CD301⁺	Irf4, Notch2, Klf4	Direct presentation IL-6, TNF-α IL-23 (intestinal and lung)	Th2 and Th17 activation
pDCs		CD11c^int, MHC-II⁻, CD45R⁺, CD45RA⁺, Siglec H⁺, PCDA-1⁺			CD11c^lo, CD123⁺, CD45RA⁺, BDCA2⁺, BDCA4⁺		E2-2, Irf8, Bcl11a, Runx2, SpiB	Type I, Type III interferons IL-12, IL-6	Antiviral immunity
moDCs		CD11c⁺, MHC-II⁺, CD11b⁺			CD11c⁺, HLA-DR⁺, CD14⁺, BDCA1⁺, FcεRI⁺, CD206⁺		Klf4, Irf8	TNF-α, IL-12, IL-23, iNOS	Th1 and Th17 response
Langerhans cells		EpCAM^hi, MHC-II⁺, CD11b⁺, CD11c⁺			CD11c^lo, CD1a^hi, Langerin⁺		Id2, Runx3	Dermal and epidermal antigen presentation IL-23, IL-6, IL-1β	Th17 response