Table 2.
Shared risk of autoimmune diseases conferred by the HLA DR3 (DRB1*0301-DQA1*0501-DQB1*0201) and DR4 (DRB1*0401-DQA1*0301)
| HLA allele | Disorder | Odd’s ratio | Reference |
|---|---|---|---|
| DR3 | Type 1 diabetes | 3.64 | [5] Erlich et al. 2008 Diabetes |
| Coeliac disease | 2.09 | [6] Liu et al. 2014 NEJM | |
| Hypothyroidism | 2.53 | [7] Zamani et al. 2000 AJMG | |
| DR4 | Type 1 diabetes | 7.03 | [5] - Erlich et al. 2008 Diabetes |
| Multiple sclerosis | 1.63 | [4] Andlauer et al. 2016 Sci Adv | |
| Rheumatoid arthritis | 2.88 | [8] Stahl et al. 2010 Nat Genet |
Odds ratios are provided for individuals carrying a single copy of each allele