Table 2.

Overlapping genes between different bone parameters and different muscle-related traits

Muscle-related trait	Gene	eBMD P value	Muscle-related traits P value	Reference
Bone mineral density
Total body lean mass	MC4R	2.0 × 10−15	1.0 × 10−18	Karasik et al. 2019
Total body lean mass	FTO	1.6 × 10−26	1.4 × 10−09	Zillikens et al. 2017
Hand grip strength	IRS1	4.7 × 10−08	1.5 × 10−11	Zillikens et al. 2017
Hand grip strength	MGMT	2.3 × 10−22	1.0 × 10−13	Tikkanen et al. 2018
Hand grip strength	TCF4	9.4 × 10−10	5.9 × 10−15	Tikkanen et al. 2018
Hand grip strength	TMEM18	2.0 × 10−11	5.4 × 10−22	Tikkanen et al. 2018
Hand grip strength	LINC01104	7.9 × 10−11	3.1 × 10−09	Tikkanen et al. 2018
Hand grip strength	MC4R	2.0 × 10−15	2.1 × 10−19	Tikkanen et al. 2018
Hand grip strength	PEX14	6.7 × 10−13	5.6 × 10−11	Willems et al. 2017
Hand grip strength	SLC8A1	7.4 × 10−38	7.7 × 10−09	Willems et al. 2017
Hand grip strength	TGFA	9.3 × 10−19	4.8 × 10−13	Willems et al. 2017
Bivariate analysis with bone strength index
Appendicular lean mass	FADS1		pb = 1.6 × 10−07	Han et al. 2012
Bivariate analysis with appendicular bone size
Appendicular lean mass	GLYAT		pb = 1.8 × 10−06	Guo et al. 2013

p_b bivariate p value for bone/muscle pair, eBMD estimated bone mineral density