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. 2019 Mar 19;9:4869. doi: 10.1038/s41598-019-41256-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Annual TB incidence by year among different acceptability levels in the elderly with LTBIs. (B) Annual TB incidence at year 2020 (red), 2025 (blue), and 2030 (green) according to acceptability levels. TST (dots line) and T-spot (dash lines) were used for LTBI screening. (C) Benefit-risk ratios at year 2020 (red), 2025 (blue), and 2030 (green) according to acceptability levels. The Benefit-risk ratios were obtained by dividing the number of active cases prevented with the number of hepatitis cases that occurred in the specified year. TB, tuberculosis; TST, tuberculin skin test.