Fig. 4. Oleate-induced decrease in β-cell function in wildtype mice is partially prevented in BESTO mice.

Plasma insulin levels (a), plasma C-peptide levels (b), sensitivity index (c), and disposition index (d) during the one-step hyperglycemic clamp. BESTO mice (TG) or wildtype (WT) littermates were treated for 48 h with either (1) saline (WTSAL, n = 8; TGSAL, n = 7) or (2) oleate at 3.9 μmol/min (WTOLE, n = 8; TGOLE, n = 8). Data are means ± SEM and refer to the last 30 min of the basal period and clamp. a–d ^##p < 0.01, ^###p < 0.001 WTOLE vs. WTSAL and TGSAL, ⁺⁺⁺p < 0.001 TGOLE vs. TGSAL and WTSAL