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. 2019 Mar 19;9:4862. doi: 10.1038/s41598-019-41340-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of Bri2 decreases mEPSC frequency and amplitude at hippocampal SC–CA3 > CA1 synapses. (a) Cumulative probability of a-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptor (AMPAR) mediated mEPSC inter-event intervals. Inset in cumulative probability graphs represents average mEPSC frequency. (b) Cumulative probability of AMPAR-mediated mEPSC amplitudes. Inset in cumulative probability graphs represents average amplitudes. (c) Decay time of mEPSC. (d) Representative traces of mEPSCs. Number of mEPSCs recordings were: 21, 18 and 18 for Itm2b^WT/WT, Itm2b^KO/WT and Itm2b^KO mice, respectively All data represent means ± SEM. Data were analyzed by Ordinary one-way ANOVA. ANOVA summary of mEPSC frequency: F = 19.11, adjusted P value < 0.0001 (significant = ****). Post-hoc Tukey’s multiple comparisons test: WT vs. Itm2b^KO/WT adjusted P value = 0.0096 (significant = **); WT vs. Itm2b^KO adjusted P value < 0.0001 (significant = ****); Itm2b^KO/WT vs. Itm2b^KO adjusted P value = 0.9935 (not significant). ANOVA summary of mEPSC amplitude: F = 8.1, adjusted P value = 0.0008 (significant = ***). Post-hoc Tukey’s multiple comparisons test: WT vs. Itm2b^KO/WT adjusted P value = 0.0027 (significant = **); WT vs. Itm2b^KO adjusted P value = 0.0038 (significant = **); Itm2b^KO/WT vs. Itm2b^KO adjusted P value = 0.8245 (not significant). ANOVA summary of mEPSCs decay time: F = 1.011, adjusted P value = 0.3772 (not significant).