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. 2019 Mar 19;9:4862. doi: 10.1038/s41598-019-41340-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Post-synaptic loss of Bri2 decreases the AMPA/NMDA ratio at hippocampal SC–CA3 > CA1 synapses. AMPA/NMDA ratio is significantly reduced in Itm2b^KO and Itm2b^CA3-KO mice. AMPAR/NMDAR ratio. Number of recordings were: 9, 8, 13 and 13 for Itm2b^f/f, Itm2b^CA1-KO, Itm2b^CA3-KO and Itm2b^KO mice, respectively. Data were analyzed by Ordinary one-way ANOVA. ANOVA summary of AMPAR/NMDAR ratio: F = 23.08, adjusted P value < 0.0001 (significant = ****). Post-hoc Tukey’s multiple comparisons test: Itm2b^f/f vs. Itm2b^CA1-KO adjusted P Value < 0.0001 (significant = ****); Itm2b^f/f vs. Itm2b^CA3-KO adjusted P Value = 0.1477 (not significant); Itm2b^f/f vs. Itm2b^KO adjusted P Value < 0.0001 (significant = ****); Itm2b^CA1-KO vs. Itm2b^CA3-KO adjusted P Value = 0.0034 (significant = **); Itm2b^CA1-KO vs. Itm2b^KO adjusted P Value = 0.5709 (not significant); Itm2b^CA3-KO vs. Itm2b^KO adjusted P Value < 0.0001 (significant = ****).