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. 2019 Mar 19;9:4851. doi: 10.1038/s41598-019-41311-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of the DPV Us5 protein on H₂O₂-induced apoptosis. (A) TUNEL assay. The arrows indicate TUNEL-positive cells. Cells transfected with the pCAGGS plasmid and treated with H₂O₂ were used as controls. (B) The activity of caspase-3/7 and caspase-9 in cells transfected with the pCAGGS-Us5 plasmid and treated with H₂O₂ and cells transfected with the pCAGGS plasmid and treated with H₂O₂. (C) H₂O₂-treated cells transfected with the pCAGGS-Us5 plasmid cloud inhibit a lot of apoptosis. All data are presented as the means ± SD from three individual experiments. p* < 0.05, p** < 0.01 compared to the non-Us5-expressing control.