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Half-maximal inhibitory concentration (IC50) of sorafenib for HepG2 spheroid (3D) and monolayer culture (2D) after 24 hours and 48 hours of drug exposure.
| Sorafenib exposure time (hours) | 3D (µM) | 2D (µM) | p-value |
|---|---|---|---|
| 24 | 47.77 ± 3.12 | 29.14 ± 1.14 | <0.05 |
| 48 | 8.40 ± 1.20 | 7.66 ± 1.02 | >0.05 |
