Table 3.

Effect of serotonin & serotonergic drugs on genetic epilepsy prone rats (effect on audiogenic seizures).

Drug and Category	Dose	Pharmacological Effect	Refs.
Fluoxetine (SSRI)	15 mg/kg	Decreased audiogenic seizures in 33% of GEPR-9s	[117]
5-Hydroxytryptophan (immediate synthetic precursor of serotonin)	12.5 mg/kg	No effect	[117]
Fluoxetine (SSRI) + 5-Hydroxytryptophan (immediate synthetic precursor of serotonin)	15 + 12.5 mg/kg	Decreased audiogenic seizures in 83% of GEPR-9s	[117]
Fluoxetine (SSRI)	15 mg/kg	No effect on audiogenic seizures in GEPR-9s	[119]
Pindolol (5-HT receptor antagonist)	10 mg/kg	No effect of audiogenic seizures in GEPR-9s	[119]
Fluoxetine (SSRI) + Pindolol (5-HT receptor antagonist)	15 + 10 mg/kg	Substantial reduction in seizure severity (i.e audiogenic seizure severity scores in GEPR-9s) (5-HT1A receptor antagonist Pindolol enhances the ability of fluoxetine to increase extracellular 5-HT in brain)	[119]
(±) LY 206130 (5-HT1A receptor antagonist)	5 mg/kg	Ineffective in suppressing audiogenic seizures in GEPR-9s	[119]
Fluoxetine + (±) LY 206130	15 + 5 mg/kg	Conspicuous reduction in seizure severity (i.e audiogenic seizure severity scores in GEPR-9s)	[119]
Paracholorophenyl alanine + Fluoxetine + (-) LY 206130	100 + 15 + 5 mg/kg	Ineffective in preventing seizures (This treatment was found to be highly effective in depleting brain 5-HT)	[119]
Fluoxetine (SSRI) + 5-hydroxytryptophan (immediate synthetic precursor of serotonin)	15 mg/kg + 12.5, 25 & 50 mg/kg	The severity of audiogenic seizures was decreased dose-dependently (The antiseizure effect was potentiated)	[144]