Table 5.

Effect of serotonin & serotonergic drugs on picrotoxin induced seizures.

Drug and Category	Dose	Pharmacological Effect	Refs.
8-OH-DPAT ((±)-8-hydroxy-2-(di-n-propylamino) tetralin)	1 & 3 mg/kg	Increased the doses of picrotoxin producing running/bouncing clonus, tonic hindlimb extension and death in stressed and unstressed mice, respectively (Anticonvulsant effect)	[123]
WAY-100635 (a selective agonist and antagonist of 5-HT1A receptors), + 8-OH-DPAT ((±)-8-hydroxy-2-(di-n-propylamino) tetralin)	0.3 mg/kg + 3 mg/kg	Pre-treatment with WAY (0.3 mg/kg) prevented the anticonvulsant effect of 8-OH-DPAT (3 mg/kg)	[123]
DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane)	2.5 mg/kg	Failed to affect seizure threshold for picrotoxin	[123]
ketanserin (a 5-HT2A/2C receptor agonist and antagonist)	1 mg/kg	Failed to affect seizure threshold for picrotoxin	[123]